Randomized Trial of Tumor Lysate Particle Only Vaccine vs. Tumor Lysate Particle-loaded, Dendritic Cell Vaccine to Prevent Recurrence of Resected Stage III/IV Melanoma: 36-MonthAnalysis – Society for Immunotherapy of Cancer

by | Nov 6, 2021 | Publications & Presentations

The TLPO and TLPLDC (without G-CSF) vaccines improved 36-month DFS and OS in this randomized phase 2 trial. The efficacy of the TLPO and TLPLDC vaccines will be confirmed in a phase III trial in resected Stage III/IV melanoma pts.

Tumor Lysate Particle Only Vaccine (TLPO) vs. Tumor Lysate Particle-loaded, Dendritic Cell (TLPLDC) Vaccine to Prevent Recurrence in Resected Stage III/IV Melanoma Patients: Results of a Phase I/IIaTrial

by | Oct 10, 2021 | Publications & Presentations

In this randomized, double-blind phase 2 trial of TLPO versus TLPLDC, both vaccines were well tolerated. There were no differences in DFS or OS in clinically disease-free melanoma pts receiving TLPO versus TLPLDC vaccines. Given prior efficacy shown with TLPLDC vs...